This Division Series saw the Yankees defeat the Twins, 3–0. The Yankees were defeated by the Texas Rangers 4–2 in the AL Championship Series (ALCS). The Rangers were defeated by the National League Champion San Francisco Giants 4–1 in the 2010 World Series.

This was the second consecutive season and fourth season overall in which the Twins and Yankees met in the ALDS; the Yankees won all their previous series, 3–1 in 2003 and 2004, and 3–0 in 2009.

This was the first time that the Yankees advanced to the second round of the postseason as the Wild Card (they lost all three in 1995, 1997, and 2007), and this win marked the ninth time the Yankees advanced to the LCS since 1995, the most in MLB.

The Minnesota Twins, with this loss, extended their postseason losing streak to twelve games, with nine of those coming against the Yankees. The Yankees extended their postseason dominance over the Twins to four consecutive series wins.